Soumya Pati

This study identifies inflammation-responsive s-acylation of key antioxidants in microglia, revealing their role in redox flexibility and schizophrenia pathology.

This study identifies SphK1 as a druggable target in human macrophages for anti-leishmanial therapy by showing its role in promoting Leishmania donovani survival through immune evasion and cell fate regulation.

This study identifies the filarial serpin Wb123 and shows it promotes macrophage alternative activation via uPAR, which is inhibited by the monoclonal antibody MAbG8.

This paper investigates how replenishing NADPH can restore redox homeostasis and lysosomal function in G6PD-deficient microglia through metabolic pathway modulation.

This study shows that G6PD deficiency in microglia impairs iNOS-mediated NO production and lysosomal acidification, leading to reduced phagocytosis of SARS-CoV-2 and increased COVID-19 severity.

This paper identifies prohibitins (PHBs) in Plasmodium falciparum as druggable targets, showing their mitochondrial localization and functional roles, and demonstrates that Rocaglamide inhibits parasite growth in multiple drug-resistant strains.

This study shows erythritol inhibits Plasmodium falciparum growth across multiple life stages and protects the blood-brain barrier, suggesting it as a potential anti-malarial compound.

The paper reports a novel tRNA-derived peptide, tREP-18, with potent anti-leishmanial activity against L. donovani and PKDL isolates.

This paper identifies PMD as a conserved region of Plasmodium perforin-like proteins that forms pores in erythrocytes, leading to anemia, and shows that anti-PMD inhibitors block parasite growth and transmission across multiple stages.