Xiaodong Cheng

This study identifies TXNIP as a downstream effector of EPAC signaling in primary melanoma, showing its role in redox regulation and melanoma progression through mTORC1 and HIF-1 pathways.

This study identifies the SUMO-interacting motif in EPAC1 as critical for its subcellular targeting and functional regulation, including cAMP binding and signaling microdomain formation.

This study identifies SUMOylation of EPAC1 at K561 as a mechanism for cAMP-independent activation of EPAC1 through enhanced Rap1 interaction.