Author

Wenli Yang

Brown Foundation Institute of Molecular Medicine for the Prevention of Human DiseasesORCID 0000-0002-4484-2280Unclaimed ORCID profile · follow to get notified of new preprints

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Wenli Yang1 paper · University of Pennsylvania

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Fang C. MeiiD· 2 shared Wei Lin· 2 shared Xiaodong ChengiD· 2 shared André HoelziD· 1 shared Christopher J. BleyiD· 1 shared Jason E. LeeiD· 1 shared Li LiiD· 1 shared Mark Andrew WhiteiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Fang C. MeiORCID

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2 papers

Recent·Most cited

Cell BiologyJournal of Biological ChemistryPeer-reviewedMay 22, 2025

A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function

Wenli Yang, Fang C. Mei, Wei Lin…·Xiaodong Cheng

This study identifies the SUMO-interacting motif in EPAC1 as critical for its subcellular targeting and functional regulation, including cAMP binding and signaling microdomain formation.

3 citations

humanproteomics

𝕏 PostBluesky

Cell BiologyCellular and Molecular Life SciencesPeer-reviewedJul 4, 2024

Protein SUMOylation promotes cAMP-independent EPAC1 activation

Wenli Yang, Fang C. Mei, Wei Lin…·Xiaodong Cheng

This study identifies SUMOylation of EPAC1 at K561 as a mechanism for cAMP-independent activation of EPAC1 through enhanced Rap1 interaction.

10 citations

humanproteomics

𝕏 PostBluesky