Author

Weidi Xie

Shanghai Jiao Tong University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:contrastive learning· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Yanfeng Wang· 2 shared Chaoyi WuiD· 1 shared Chunhao Zhu· 1 shared H. Eric XuiD· 1 shared Jian ZhangiD· 1 shared Jiaxuan HaniD· 1 shared Jin ZhuoiD· 1 shared Jinghao Feng· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

Yanfeng Wang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RELAY: Relational In-Context Learning for Cellular Perturbation Prediction

Yuze Sun, Jinghao Feng, Yanfeng Wang, Weidi Xie, Ya Zhang, Xiaoman Zhang

RELAY predicts cellular responses to perturbations by learning relational patterns from measured data, outperforming existing methods on unseen variable values and combinations.

bioRxiv · Nov 3, 2026 · PreprintCell Biology

Fine-tuning an intracellular allosteric pocket programs GPCR signaling bias

Xinchao Shi, Ruidi Zhu, Kewei CHANG, Peng Yu, Qingning Yuan, 张云云, Xun Lu, Ziwei Zhou, Chunhao Zhu, Xiaobing Lan, Mingyu Li, Rui Li, Xin Qiao, Weidi Xie, Youwen Zhuang, , Jian Zhang

This study fine-tunes an intracellular allosteric pocket of NTSR1 to program GPCR signaling bias, revealing how ligand modifications alter transducer coupling and downstream signaling.

bioRxiv · Oct 27, 2026 · PreprintPharmacology & Toxicology

ASOCompass: Context- and Chemistry-Aware Activity Prediction for Transferable Antisense Oligonucleotide Screening

Shuyu Liu, Jin Zhuo, Shuchang Lei, Tianhao Wu, Jiaxuan Han, Chaoyi Wu, Yanfeng Wang, Weidi Xie

ASOCompass predicts ASO activity by integrating sequence, chemistry, and biological context, achieving higher correlation than baselines across diverse conditions.

bioRxiv · Aug 7, 2026 · PreprintBioinformatics