Author

Kewei CHANG

Shanghai Jiao Tong University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Chunhao Zhu· 2 shared Jian ZhangiD· 2 shared Mingyu Li· 2 shared Xiaobing Lan· 2 shared Xinchao ShiiD· 2 shared Youwen ZhuangiD· 2 shared Chaoran ChengiD· 1 shared Cui Yunxia· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPharmacology & Toxicology

Chunhao Zhu

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Author profile →

2 papers

Recent·Most cited

Fine-tuning an intracellular allosteric pocket programs GPCR signaling bias

Xinchao Shi, Ruidi Zhu, Kewei CHANG, Peng Yu, Qingning Yuan, 张云云, Xun Lu, Ziwei Zhou, Chunhao Zhu, Xiaobing Lan, Mingyu Li, Rui Li, Xin Qiao, Weidi Xie, Youwen Zhuang, , Jian Zhang

This study fine-tunes an intracellular allosteric pocket of NTSR1 to program GPCR signaling bias, revealing how ligand modifications alter transducer coupling and downstream signaling.

bioRxiv · Oct 27, 2026 · PreprintPharmacology & Toxicology

Accurate de novo design of peptides from programming biophysical landscape

Mingyu Li, Yini Liu, Jie Zhong, Xinchao Shi, Jiqing Zheng, Kai Wang, Cui Yunxia, Chaoran Cheng, Shijin Li, Xiangzhe Kong, S W Li, Miaojie Xv, Chunhao Zhu, Xiaobing Lan, He Yang, , Jian Zhang

NeoPep designs functional peptides de novo using a deep-learning framework that models biophysical principles, achieving high hit rates and structural accuracy across diverse targets.

bioRxiv · Jun 9, 2026 · PreprintMolecular Biology