Rui Li

Fine-tuning an intracellular allosteric pocket programs GPCR signaling bias

This study fine-tunes an intracellular allosteric pocket of NTSR1 to program GPCR signaling bias, revealing how ligand modifications alter transducer coupling and downstream signaling.

Isolation, extraction, and physicochemical characterization of exosome-like nanovesicles from ginseng adventitious roots in tissue culture

This study isolates and characterizes exosome-like nanovesicles from ginseng adventitious roots and shows that MeJA increases their yield and active components.

A structure-informed deep learning framework for modeling TCR-peptide-HLA interactions

StriMap models TCR-peptide-HLA interactions using structural and sequence features, achieving state-of-the-art performance and identifying disease-associated peptides in ankylosing spondylitis.

A Distal Super-Enhancer Regulate CD47 Expression and Promotes Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells

The paper identifies a distal super-enhancer regulating CD47 expression in ovarian cancer, linking it to macrophage-mediated phagocytosis of cancer cells.

Insulin receptor substrate 2 (IRS2) confers resistance to PI3K pathway inhibition in PIK3CA mutant breast cancer

This study identifies IRS2 as a mediator of resistance to PI3K pathway inhibitors in PIK3CA mutant breast cancer by sustaining PI3K signaling through FOXO3-mediated regulation.

VASP Promotes Aortic Valve Calcification by Interacting with FBLIM1 to Activate the Focal Adhesion Pathway

This study identifies VASP as a key driver of aortic valve calcification through its interaction with FBLIM1 to activate the focal adhesion pathway, promoting calcification and elastin secretion.

Preserving Integrity: Innovative In Vitro Methods for Extracellular Matrix Decellularization and Collagen Purification

The paper develops and validates new methods for ECM decellularization and collagen purification that preserve structural and biochemical integrity, applicable to various cell types for tissue engineering and drug discovery.

Multiomics reveals epigenetic control of fibroblast activity after myocardial infarction and a key role for RUNX transcription factors

This study uses multi-omics approaches to show that Runx1 regulates cardiac fibroblast activity and differentiation after myocardial infarction, with its deletion improving cardiac repair.

UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold Exposure

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals

This study detects HIV-1 antisense transcripts in vivo, showing higher expression in ART-treated individuals compared to untreated ones, suggesting a regulatory role in viral expression.

Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

Epigenetic silencing and blockade of latency reversal by an HIV-1 encoded antisense transcript

This study identifies an HIV-1 antisense transcript that enforces latency by inducing epigenetic silencing and blocks latency reversal in CD4+ T-cells.

Mitochondrial DNA Variations Modulate Alveolar Epithelial Mitochondrial Function and Oxidative Stress in Newborn Mice Exposed to Hyperoxia

This study shows that mtDNA variations affect mitochondrial function and oxidative stress in newborn mice exposed to hyperoxia, with implications for BPD risk in human infants.

Generation and Validation of Versatile Inducible CRISPRi Embryonic Stem Cell and Mouse Models

This paper develops an inducible CRISPRi system in mouse embryonic stem cells and generates a knockin mouse model for gene function studies.

Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis (ALS)

This study investigates altered glucose-fatty acid flux in ALS using mouse models and patient-derived myotubes, finding increased fatty acid oxidation linked to slower disease progression but with metabolic heterogeneity across patients.

A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth

The paper presents a chromosome-level genome of black rockfish, identifies candidate genes related to viviparity, and proposes a reproductive model.