Mingyu Li

Genome evolution and glycosyltransferase diversification shape asperosaponin biosynthesis in Dipsacus asperoides

The paper reconstructs the asperosaponin biosynthesis pathway in Dipsacus asperoides by integrating genomics, transcriptomics, and biochemical analyses, revealing gene family diversification and glycosylation order.

Beyond Imbalance: An Elasticity Framework for the Distance-averaged Force-Velocity Relationship in Vertical Jump

This paper develops an elasticity framework to quantify how force-velocity relationship variables affect jump height and provides metrics for training prescription.

Fine-tuning an intracellular allosteric pocket programs GPCR signaling bias

This study fine-tunes an intracellular allosteric pocket of NTSR1 to program GPCR signaling bias, revealing how ligand modifications alter transducer coupling and downstream signaling.

Accurate de novo design of peptides from programming biophysical landscape

NeoPep designs functional peptides de novo using a deep-learning framework that models biophysical principles, achieving high hit rates and structural accuracy across diverse targets.

Large-scale quantum computing framework enhances drug discovery in multiple stages

This paper presents a quantum computing framework for drug discovery that improves stability and performance in multiple stages, identifying novel druggable sites and compounds.

AI2BMD: efficient characterization of protein dynamics with ab initio accuracy

AI2BMD efficiently simulates large biomolecules with ab initio accuracy, outperforming DFT in speed while maintaining chemical accuracy for dynamics and free energy calculations.

Genome sequencing of the perciform fish Larimichthys crocea provides insights into stress adaptation

This study sequenced the genome of the large yellow croaker to understand its adaptation to environmental stress, finding expanded gene families and novel regulatory networks involved in stress response.