Structural Rewiring of IL-7R Dimerization by an Oncogenic Transmembrane Mutation Can Be Reversed by Rational Design
Qian Wang, Min Chen, Asma Lasram, Saana Vihuri, Angela Chou, Weixin Bian, Zhiming Dai, Outi Haapanen, Giray Enkavi, Christoph Pollmann, Ilpo Vattulainen, Tiantian Cai, Jacob Piehler, James Jeiwen Chou
This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.
Proceedings of the National Academy of Sciences · Apr 28, 2026Peer-reviewedBiophysics