James Jeiwen Chou

This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.

This study identifies a small molecule that inhibits melanoma migration and metastasis by targeting the transmembrane domain of p75NTR, showing promise for cancer treatment.

This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.