Jacob Piehler

This study reports cryo-EM structures of human ABCA2, revealing its cholesterol transport mechanism and novel conformational changes.

This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.

This study uses metal-induced energy transfer to reveal that cytokine receptor intracellular domains compact upon activation.

This paper introduces a nanopatterning toolbox to study multiprotein assemblies in live cells, demonstrating its application to the myddosome complex and revealing nanoscale organization.

This study uses single-molecule tracking to show that Lrp6 and Ror2 co-assemble into hybrid Wnt signalosomes dynamically.

This study determines the structure of TIRAP filaments and identifies the role of the N-terminal PBM in regulating their assembly and function at the plasma membrane.

The paper develops an in vitro assay to study HKI-VDAC1 complex assembly and shows the critical role of a bilayer-facing glutamate in pH-sensitive binding.

The paper designs proteins with controlled dissociation rates by introducing strained excited states, enabling rapid cytokine receptor dissociation.

This paper designs and characterizes agonists that tune G-CSFR activity to bias granulopoiesis over proliferation, showing improved stability and selectivity compared to native G-CSF.

The paper uses magnetic micromanipulation to show Rab25 vesicles directly drive F-actin protrusions, enhancing cancer cell invasive migration.

The paper visualizes GSDMD nanostructures at the plasma membrane of pyroptotic cells and identifies PI(3,4,5)P3 as a regulator of pore formation.

This study reveals the structure and mechanism of Leptin-mediated LEP-R assembly, showing a 3:3 stoichiometry and highlighting the role of Leptin restructuring in activating signaling.

The paper investigates how differential STAT binding to receptor phospho-Tyr motifs influences cytokine responses, showing altered dynamics in autoimmune disorders like SLE.