Author

Wen J. Aw

Hauptman-Woodward Medical Research Institute

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

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Daniel T. GewirthiD· 1 shared Gabriela ChiosisiD· 1 shared Nanette L. S. QueiD· 1 shared Paul M. SeidleriD· 1 shared

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2024-2024 · peak 1/yr

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1 shared paperBiochemistry

Daniel T. GewirthORCID

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1 paper

Recent·Most cited

BiochemistryProteins Structure Function and BioinformaticsPeer-reviewedOct 29, 2024

Selective inhibition of hsp90 paralogs: Uncovering the role of helix 1 in Grp94-selective ligand binding

Nanette L. S. Que, Paul M. Seidler, Wen J. Aw…·Daniel T. Gewirth

This study investigates how Grp94-selective ligands bind to Grp94 and Hsp90 by analyzing structural changes and identifies helix 1 as a key determinant of selectivity.

6 citations

structural biologyexperimental assay

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