Author

William Pinney

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Darrell J. IrvineiD· 2 shared Elizabeth FinkiD· 2 shared Jordan A. StinsoniD· 2 shared Karl Dane WittrupiD· 2 shared Lauren DuhameliD· 2 shared Alessia LiguoriiD· 1 shared Amanda MetziD· 1 shared Amelia Zhou· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Darrell J. IrvineORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Engineering hyaluronic acid-binding cytokines for enhanced tumor retention and safety

Elizabeth Fink, William Pinney, Lauren Duhamel, Riyam Al Msari, David Krum, Jordan A. Stinson, Karl Dane Wittrup

This study compares hyaluronic acid and collagen anchoring strategies for cytokine delivery, finding hyaluronic acid improves tumor retention and safety.

bioRxiv · Apr 8, 2026 · PreprintBioengineering

CD45 sequestration lowers the signaling threshold in lymphocytes and enhances anti-tumor immunity

Lauren Duhamel, Yiming J. Zhang, William Pinney, Elizabeth Fink, Qingyang Henry Zhao, Anna M. Romanov, Jordan A. Stinson, Luciano Santollani, Joseph R. Palmeri, Owen T. Porth, Darrell J. Irvine, Karl Dane Wittrup

This study shows that CD45 sequestration lowers T cell activation thresholds and enhances anti-tumor immunity when combined with IL-12 therapy in mouse models.

bioRxiv · Jul 29, 2025 · PreprintImmunology

Diverse priming outcomes under conditions of very rare precursor B cells

Patrick J. Madden, Ester Marina-Zárate, Kristen A. Rodrigues, Jon M. Steichen, Monolina Shil, Kaiyuan Ni, Katarzyna Kaczmarek Michaels, Laura Maiorino, Amit A. Upadhyay, Swati Saha, Arpan Pradhan, Oleksandr Kalyuzhiny, Alessia Liguori, Paul G. Lopez, Ivy Phung, , Shane Crotty

The paper investigates how vaccine antigen delivery and adjuvant selection affect the priming of rare HIV broadly neutralizing antibody-precursor B cells in non-human primates, finding that specific dosing and adjuvant combinations enhance their detection in germinal centers.

Immunity · Apr 1, 2025Peer-reviewedImmunology