ImmunologybioRxivPreprint
CD45 sequestration lowers the signaling threshold in lymphocytes and enhances anti-tumor immunity
Lauren Duhamel, Yiming J. Zhang, William Pinney…·Karl Dane Wittrup
This study shows that CD45 sequestration lowers T cell activation thresholds and enhances anti-tumor immunity when combined with IL-12 therapy in mouse models.
DOI 10.1101/2025.07.29.667400