Karl Dane Wittrup

This study compares hyaluronic acid and collagen anchoring strategies for cytokine delivery, finding hyaluronic acid improves tumor retention and safety.

This study shows PD-1 blockade during T cell priming promotes an intermediate-exhausted CD8 T cell state that supports durable anti-tumor immunity after surgery and metastatic challenge, better than effector or memory-like T cells.

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.

This study shows that CD45 sequestration lowers T cell activation thresholds and enhances anti-tumor immunity when combined with IL-12 therapy in mouse models.

This study develops CD45-targeted immunocytokines that localize to immune cells in tumors and lymph nodes, eradicating both treated and distant tumors in mouse models.

This study evaluates collagen-binding IL-2 and IL-12 in pet dogs with melanoma, showing local and regional therapeutic responses that suggest potential human clinical benefit.