Author

X. Hanoulle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

C. Danis· 2 shared E. Dupre· 2 shared F.-X. Cantrelle· 2 shared I. Landrieu· 2 shared J. Mortelecque· 2 shared J.-C. Rain· 2 shared M. Colin· 2 shared O. Zejneli· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

C. Danis

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2 papers

Recent·Most cited

BiochemistrybioRxivJul 18, 2023

Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

J. Mortelecque, O. Zejneli, S. Begard…·E. Dupre

The paper optimizes VHH antibodies targeting Tau's PHF6 peptide through mutagenesis and screening, showing improved binding and aggregation inhibition, but also highlighting the importance of stability beyond affinity.

DOI 10.1016/j.jbc.2024.107163

protein structureexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivMar 23, 2021

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

C. Danis, E. Dupre, O. Zejneli…·I. Landrieu

This study identifies and optimizes a single domain antibody fragment that inhibits Tau aggregation in vitro and in a mouse model of tauopathy.

DOI 10.1016/j.ymthe.2022.01.009

mouseproteomics

𝕏 PostBluesky