GeneticsbioRxivPreprint
Structural semantic evolutionary distance (SSED) unifies the selection of cancer driver genes across macroevolution and tumorigenesis.
Hongchen Ji, Q Y Zhang, Jianwei Wu…·Hong-Mei Zhang
This paper introduces SSED, a metric using ESM-3 to quantify evolutionary divergence, showing cancer driver genes are structurally constrained and that oncogenic mutations follow similar principles, predicting immune response.
DOI 10.64898/2025.12.17.694808