Geranylgeranyl pyrophosphate (GGPP) is associated with hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4
C. Li, Y. Zhao, S. Jiang, H.-Y. Nie, M.-F. Zhao, P. Sun, J.-Z. Zhang, X.-C. Wang, Y.-P. Tang, X.-W. Yuan, X.-T. Sun, X.-D. Shan, J. He, J.-H. Liu, Y. Bi, , X. Han
This study shows GGPP promotes hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4, and inhibiting GGPP synthase reduces these effects.
bioRxiv · Sep 19, 2023 · PreprintPathology