Author

Xiang Chen

Jilin University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:protein sequence· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Pu TianiD· 2 shared Alex J. SmithiD· 1 shared Charlotte Helena RivasiD· 1 shared Cheng HeiD· 1 shared Dane K. HoffmaniD· 1 shared David Glenn Edwards· 1 shared Diego A. PedrozaiD· 1 shared Emmanuel AnningiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioinformatics

Pu TianORCID

Author profile →

4 papers

Recent·Most cited

Characterization of cross-family conserved fragments

Xiang Chen, Pu Tian

The paper characterizes cross-family conserved fragments, showing their structural and biophysical properties and their role in folding and stability.

bioRxiv · Oct 6, 2026 · PreprintBioinformatics

Early dynamics of a neutrophil interferon program drive immunotherapy resistance and limit durable anti-tumor immunity

Yang Gao, Emmanuel Anning, Linhua Wang, Yating Cheng, Ling Wu, Jun Wang, Fengshuo Liu, Zhan Xu, Xiaoxin Hao, Jun Liu, Liqun Yu, Yunfeng Ding, Weijie Zhang, David Glenn Edwards, Yi-Hsuan Wu, , Xiang H.-F. Zhang

This study identifies an early neutrophil interferon program that predicts resistance to anti-PD1 therapy and limits durable anti-tumor immunity.

bioRxiv · Oct 1, 2026 · PreprintCancer Biology

ProDive: detecting cross-family local conservation

Xiang Chen, Pu Tian

ProDive detects cross-family local conservation using a pHMM-based framework, identifying 318,289 high confidence segment correspondences across 25,545 Pfam families.

bioRxiv · Sep 28, 2026 · PreprintBioinformatics

SLC44A1 deficiency impedes myelin development in the central nervous system

Qiang Chen, Xiang Chen, Zhenghao Li, Qi Shao, Hao Huang, Wenhao Zhou, Mengsheng S. Qiu, Zhida Su, Peng Liu, Cheng He

This study shows that SLC44A1 is critical for myelin development in the CNS and that citicoline supplementation can restore myelination in deficient animals.

Cell Reports · Nov 27, 2025Peer-reviewedNeuroscience