Early dynamics of a neutrophil interferon program drive immunotherapy resistance and limit durable anti-tumor immunity
Yang Gao, Emmanuel Anning, Linhua Wang, Yating Cheng, Ling Wu, Jun Wang, Fengshuo Liu, Zhan Xu, Xiaoxin Hao, Jun Liu, Liqun Yu, Yunfeng Ding, Weijie Zhang, David Glenn Edwards, Yi-Hsuan Wu, , Xiang H.-F. Zhang
This study identifies an early neutrophil interferon program that predicts resistance to anti-PD1 therapy and limits durable anti-tumor immunity.
bioRxiv · Oct 1, 2026 · PreprintCancer Biology