Molecular BiologybioRxivPreprint
Super Enhancer-driven LncRNA UNC5B-AS1 Inhibits Inflammatory Phenotypic Transition in Smooth Muscle Cells via Lactylation Modification
Xiangrui Zhu, Xiangming Pang, Xiaoying Wang…·Cui Ma
This paper identifies UNC5B-AS1, a super enhancer-driven lncRNA, as a regulator of inflammatory phenotypic transition in PASMCs under hypoxia, showing its role in stabilizing mitochondrial complex IV interactions and modulating lactylation of inflammatory gene promoters.
2 citations