Author

Xiangyi Fang

Harold C. Simmons Comprehensive Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 2 Organism:mouse· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Meng-Hsiung HsiehiD· 2 shared Qiyu Zeng· 2 shared Tripti SharmaiD· 2 shared Xiongzhao Ren· 2 shared Xun WangiD· 2 shared Zhijie LiiD· 2 shared Ahmad Al Kawam· 1 shared Alisa Arutyunova· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCancer Biology

Meng-Hsiung HsiehORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Somatic TYK2 activating mutations in tumor-infiltrating T cells promote anti-cancer immunity

Zhijie Li, Meng-Hsiung Hsieh, Alisa Arutyunova, John Evans, Tao Liu, Andrew R. J. Lawson, Pantelis A. Nicola, Gerda Kildisiute, Heather E. Machado, Ahmad Al Kawam, Rui Wang, Qiyu Zeng, Nisi Jiang, Xun Wang, Gregory Mannino, , Hao Zhu

The paper identifies somatic TYK2 mutations in TILs that enhance anti-cancer immunity and shows their therapeutic potential through mouse models.

bioRxiv · Oct 13, 2025 · PreprintCancer Biology

Mechanistic basis for protection against fatty liver disease by CIDEB loss-of-function mutations

Qiyu Zeng, Satish Patel, Xun Wang, Meng-Hsiung Hsieh, Zhijie Li, Xiongzhao Ren, Jingjing Wang, Dohun Kim, Shili Li, Xinping Gu, Greg Mannino, Gianna Maggiore, Xiangyi Fang, Lin Li, Min Zhu, , Hao Zhu

This study investigates how CIDEB loss-of-function mutations protect against fatty liver disease by enhancing β-oxidation through ATGL and PPARα activation.

bioRxiv · Apr 1, 2025 · PreprintPhysiology

Reconstructing tumor evolution without chromosomal instability reveals in vivo determinants of therapeutic response

Ruhollah Moussavi-Baygi, Matthew J. Ryan, Woogwang Sim, Samuel B Hoelscher, Valbona Luga, Arun A. Chandrakumar, Lore Hoes, Junghwa Cha, Young Sun Lee, Katelyn Herm, Ben Doron, Danika Bakke, Sharon Wu, C.K. Cornelia Ding, Bradley A. Stohr, , Rohit Bose

This study develops an in vivo platform called SETs to reconstruct tumor evolution without chromosomal instability, identifying therapeutic response determinants in prostate cancer.

bioRxiv · Mar 17, 2025 · PreprintCancer Biology