Xun Wang

This study identifies HSD17B7 as critical for sensory hair cell function by regulating cholesterol synthesis, showing its role in auditory physiology and hearing loss.

The paper identifies somatic TYK2 mutations in TILs that enhance anti-cancer immunity and shows their therapeutic potential through mouse models.

This study investigates how CIDEB loss-of-function mutations protect against fatty liver disease by enhancing β-oxidation through ATGL and PPARα activation.

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.