Pharmacology & ToxicologybioRxivPreprint
Multidimensional Mechanistic Study of Panax Notoginseng Saponins in the Treatment of Alcohol-Induced Osteonecrosis of the Femoral Head: Integrating Network Pharmacology, Molecular Dynamics Simulation and In Vivo Validation
Ruokun Bai, Hua Su, Jian Mo…·Liang Bing
This study identifies PNS active components, targets, and pathways for AIONFH using network pharmacology, molecular dynamics, and animal experiments, showing PNS inhibits osteocyte apoptosis through multi-component, multi-target mechanisms.
DOI 10.64898/2026.04.28.721283