Xin Shen

Endocardial TIE1 synergizes with TIE2 to regulate the atrial internal muscular network assembly

This study shows TIE1 and TIE2 work together in atrial development, with TIE1 specifically needed for atrial muscular network formation.

Endothelial ANGPT2 insufficiency impairs retinal vascularization with ROP-like neovascular tufts

This study shows that endothelial ANGPT2 deficiency causes retinal vascular defects similar to retinopathy of prematurity, with impaired tip cell invasion and hypoxia-driven changes.

Lymphatics unload VEGFR3 in response to the alteration of VEGFR2-mediated transcriptional programs

This study shows that VEGFR2 is essential for maintaining lymphatic endothelial identity and its loss alters transcriptional programs, reducing VEGFR3-mediated lymphangiogenesis.

ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes

This study identifies ATF6 as a regulator of angiogenesis-osteogenesis coupling in ankylosing spondylitis by enhancing FGF2 expression in chondrocytes.

The Evolutionary Landscape of Pan-Cancer Drives Clinical Aggression

This study identifies four pan-cancer evolutionary patterns linked to clinical aggressivity using Bayesian mutation landscape analysis across 21 cancer types.