Genetic & Genomic MedicinemedRxivPreprint
Disentangling phenotype scale, amplification, and effect heterogeneity underlying polygenic GxE architecture of complex traits
Zhengtong Liu, Aakarsh Anand, Xinyue Qie…·Sriram Sankararaman
This paper introduces REGENA, a method to disentangle gene-environment interaction mechanisms, finding that half of significant GxE signals are scale-dependent and effect heterogeneity drives most remaining GxE heritability.
DOI 10.64898/2026.10.15.26365681