Author

Xuan Lu

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Hening LiniD· 2 shared Adam FranciscoiD· 1 shared Annette ChoiiD· 1 shared Byunghyun AhniD· 1 shared Cong-Hui YaoiD· 1 shared Em Lundberg· 1 shared gary whittaker· 1 shared J. Christopher FrommeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

Hening LinORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Development of GS-441524 Derivatives as Potent SARS-CoV-2 Mac1 Inhibitors via a Direct-to-Biology Approach

Kewen Peng, Suryadeep Chakraborty, Shamar D. Wallace, Jéssica Caroline Gomes Noll, Jialin Shang, Xuan Lu, Annette Choi, gary whittaker, J. Christopher Fromme, Hening Lin

The paper develops potent SARS-CoV-2 Mac1 inhibitors through a direct-to-biology approach, improving the potency of GS-441524 to KP-S54 with IC50 values of 44 nM and 91 nM against SARS-CoV-2 and MERS-CoV Mac1, respectively.

European Journal of Medicinal Chemistry · Aug 28, 2026Peer-reviewedPharmacology & Toxicology

Coenzyme A is a redox sensing cofactor for malic enzyme 2 regulating oxidative stress and mitochondrial metabolism

Wenzhe Chen, Ornella D. Nelson, Xiaorong Li, Manfeng Zhang, Xuan Lu, Tao Yu, Cong-Hui Yao, Shuai Zhang, Yugang Zhang, Adam Francisco, Byunghyun Ahn, Em Lundberg, Minsu Song, Janane F. Rahbani, Zhongzhou Chen, Hening Lin

This study identifies CoA as a redox-sensing cofactor for ME2, showing it regulates oxidative stress and mitochondrial metabolism through conformational changes and NADPH production.

bioRxiv · Apr 28, 2026 · PreprintBiochemistry