J. Christopher Fromme

The paper develops potent SARS-CoV-2 Mac1 inhibitors through a direct-to-biology approach, improving the potency of GS-441524 to KP-S54 with IC50 values of 44 nM and 91 nM against SARS-CoV-2 and MERS-CoV Mac1, respectively.

This study identifies Avl9 as a GTPase-activating protein for Arf1, showing its role in secretion and cell migration and suggesting other DENN domain proteins may also function as GAPs.

The paper determines the cryoEM structure of the Ric1-Rgp1-Rab6 complex, revealing its mechanism for Rab6 activation and identifying a novel RabGEF domain and arrestin fold interactions.

The paper shows that high ATML1 concentrations induce VLCFA synthesis, which maintains giant cell identity by promoting auto-activation through lipid ligand binding.

This study determines the cryoEM structure of autoinhibited Sec7 and proposes an active conformation model based on functional and structural analyses.

This study identifies SMOC-1's dual role in regulating BMP signaling through interactions with glypican and BMP in C. elegans.