Author

Wenzhe Chen

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Hening LiniD· 2 shared Adam FranciscoiD· 1 shared Byunghyun AhniD· 1 shared Cong-Hui YaoiD· 1 shared Em Lundberg· 1 shared George E. MaioiD· 1 shared Janane F. RahbaniiD· 1 shared Jiaqi ZhaoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Hening LinORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Coenzyme A is a redox sensing cofactor for malic enzyme 2 regulating oxidative stress and mitochondrial metabolism

Wenzhe Chen, Ornella D. Nelson, Xiaorong Li, Manfeng Zhang, Xuan Lu, Tao Yu, Cong-Hui Yao, Shuai Zhang, Yugang Zhang, Adam Francisco, Byunghyun Ahn, Em Lundberg, Minsu Song, Janane F. Rahbani, Zhongzhou Chen, Hening Lin

This study identifies CoA as a redox-sensing cofactor for ME2, showing it regulates oxidative stress and mitochondrial metabolism through conformational changes and NADPH production.

bioRxiv · Apr 28, 2026 · PreprintBiochemistry

DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven pancreatic cancers

Wenzhe Chen, George E. Maio, Xiao Chen, Xuan Lü, Jiaqi Zhao, Neha Arora, Yinong Liu, Leah M. Ziolkowski, Kay F. Macleod, Yong Zhou, Hening Lin

This study identifies DHHC7 as a palmitoyl transferase that modifies KRAS4A, enhancing its membrane localization and activation, and shows that targeting DHHC7 inhibits pancreatic tumor growth.

bioRxiv · Apr 2, 2026 · PreprintCancer Biology