Hening Lin

This study identifies HDAC5 as a regulator of effector competence in human CD8+ T cells, showing it modulates cytokine responses and TCR activation through an ACTL6A-IRF4 axis.

This study shows that FAK activation drives PAO-induced skin injury by disrupting focal adhesions, and inhibiting FAK protects against vesicant-induced damage.

The paper develops potent SARS-CoV-2 Mac1 inhibitors through a direct-to-biology approach, improving the potency of GS-441524 to KP-S54 with IC50 values of 44 nM and 91 nM against SARS-CoV-2 and MERS-CoV Mac1, respectively.

This study identifies SIRT2 as a regulator of translation by deacetylating and stabilizing 4EBP1, which suppresses protein synthesis under amino acid limitation.

This study identifies CoA as a redox-sensing cofactor for ME2, showing it regulates oxidative stress and mitochondrial metabolism through conformational changes and NADPH production.

The paper develops a high-throughput fluorescence polarization assay to screen SIRT1-3 inhibitors, showing improved efficiency and performance compared to existing methods.

This study identifies SIRT5 as a regulator of endothelial cell metabolism in the tumor microenvironment, showing its role in supporting breast cancer growth through vascular function.

This study identifies DHHC7 as a palmitoyl transferase that modifies KRAS4A, enhancing its membrane localization and activation, and shows that targeting DHHC7 inhibits pancreatic tumor growth.

The paper identifies a novel F-actin binding motif in Lfat1, a Legionella effector, using cryo-EM and shows its lysine fatty-acyltransferase activity.

This study identifies SIRT2 as a regulator of global protein synthesis by modulating Rheb-GTPase activity, showing its potential as a therapeutic target for diseases with increased protein synthesis.

The paper shows that SIRT2 deacetylates ACSS2 at K271 under amino acid stress, leading to its degradation and reduced lipogenesis.

This study identifies ZDHHC7-mediated palmitoylation of NLRP3 at Cys126 as critical for inflammasome activation, with implications for therapeutic targeting of inflammatory diseases.

The paper identifies lysophospholipids as activators of pannexin channels, showing they trigger ATP and other metabolite release, and activate inflammasomes in human monocytes.

This study identifies lysine succinylation as a post-translational modification linked to amyloid and tau pathology in Alzheimer's disease through human brain and mouse model analyses.