The Ins and Outs of Manganese: ZIP14 facilitates the efflux of excess manganese from the brain.
J Zou, Trista Lee Thorn, Z Wang, Y Wang, Tolunay Beker Aydemir
This study shows ZIP14 facilitates manganese efflux from the brain by relocalizing to the basolateral membrane in BBB endothelial cells, and its deletion causes Mn accumulation.
bioRxiv · Jul 2, 2025 · PreprintPhysiology