Yao Yu Yeo

This study uses a genome-wide CRISPR-Cas9 screen to identify host factors essential for EBV B cell infection, revealing new pathways and potential therapeutic targets.

The paper identifies IL13-driven immune-epithelial remodeling in the nasal epithelium that restricts respiratory virus infection by reshaping the mucus barrier.

This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.

This study shows SARS-CoV-2 Nsp15 inhibits cGAS-STING-mediated antiviral responses by reducing cGAS and STING expression, thereby enhancing viral replication.

The paper introduces two methods to profile functional glycan-lectin interactions in tissues using single-cell and spatial multiomic approaches, revealing stimulus-specific glycan remodeling and spatial glycan programs in immune cells and follicular lymphoma.

The paper constructs an integrated atlas of tumor-infiltrating dendritic cells across species and immunotherapy conditions, revealing conserved activation states and spatial reorganization in response to therapy.

PASTA enhances spatial biology detection sensitivity while maintaining compatibility with multiple modalities and multiplexing strategies.

This study introduces MicroCart, a framework for spatial multi-omics analysis of host-microbiome interactions in colitis, revealing tissue-level immune responses and microbial shifts.

This paper introduces IN-DEPTH and SGCC for spatial multi-omics analysis, revealing EBV-related immunomodulatory differences in DLBCL.

This paper introduces CellSNAP, a self-supervised method that integrates spatial, transcriptomic, and proteomic data to improve cell population delineation in spatial-omics datasets.

This paper introduces SpaGFT, a graph Fourier transform model for spatial omics data analysis, enabling accurate identification of tissue modules and their functional relationships in spatial transcriptomics and proteomics data.