NeuroscienceJournal of Inflammation ResearchPeer-reviewed
Microglial epigenetic memory is associated with accelerated resolution of inflammatory pain induced by prophylactic macrophage-derived small extracellular vesicles
Xuan Luo, Jason R. Wickman, Jason DaCunza…·Seena K. Ajit
The paper shows that macrophage-derived sEVs reduce inflammatory pain by reprogramming microglial epigenetic memory, specifically through H3K4me1 enrichment and SETD7 inhibition.
DOI 10.2147/jir.s598095