APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids
J. Zhao, T. C. Ikezu, W. Lu, J. R. Macyczko, Y. Li, L. J. Lewis-Tuffin, Y. A. Martens, Y. Ren, Y. Zhu, Y. Asmann, N. Taner, T. Kanekiyo, G. Bu
This study shows that APOE deficiency in human iPSC-derived cerebral organoids disrupts lipid homeostasis and affects cholesterol biosynthesis and neurogenesis.
bioRxiv · Jun 30, 2022Cell Biology