Y. Ren

CREEPING STEM1 Regulates Directional Auxin Transport for Lodging Resistance in Soybean

This study identifies the CS1 gene in soybean, which regulates directional auxin transport and enhances lodging resistance, improving yield under high planting density.

Radiation dermatitis in the hairless mouse model mimics human radiation dermatitis

This study establishes a hairless mouse model of radiation dermatitis that mimics human disease, showing severe skin injury and specific histopathological markers for preclinical research.

3D Imaging Reveals Changes in the Neurovascular Architecture of the Murine Calvarium with Aging

This study uses 3D imaging to analyze changes in the neurovascular architecture of the murine calvarium across aging, revealing age-related nerve loss and vascular changes.

Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess Desulfovibrio through gut-liver axis

The paper shows that restricting sulfur-containing amino acids reduces liver injury caused by excess Desulfovibrio by lowering bile acids and improving liver function.

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model

This paper develops a semi-automated cell tracking protocol to quantify neutrophil swarming in a mouse femur model with and without S. aureus infection, showing increased speed, displacement, and directionality in infected mice.

Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

Structural adaptability and surface activity oftardigrade-inspired peptides

This paper studies model peptides derived from tardigrade proteins to mimic their structural behavior under desiccation, finding they adopt helical structures similar to full proteins.

A mechanical circuit in End4p coordinates force transmission during clathrin-mediated endocytosis

This study identifies a mechanical circuit in End4p that regulates force transmission during clathrin-mediated endocytosis in fission yeast.

CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.

Integrated transcriptome and lineage analyses reveal novel catecholaminergic cardiomyocytes contributing to the cardiac conduction system in murine heart

This study identifies a novel catecholaminergic cardiomyocyte population expressing Dbh that contributes to the murine cardiac conduction system through transcriptomic, genetic, and optogenetic analyses.

The molecular mechanism of chloramphenicol and thiamphenicol resistance mediated by a novel oxidase CmO in Sphingomonadaceae

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

Endogenous Plasmids and Reductive Genome Evolution in Host-Associated Bacteria

This study investigates reductive genome evolution in Cardinium endosymbionts, identifying endogenous plasmids and their enzymes as drivers of genome reduction.

UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells

This study shows UPF3A is not required for NMD in mouse pluripotent and somatic cells, and may only weakly promote NMD in some tissues.

Reducing chlorophyll level in seed filling stages results in higher seed nitrogen without impacting canopy carbon assimilation

This study shows reducing chlorophyll in tobacco during seed filling stages increases seed nitrogen by 17% without affecting canopy carbon assimilation or biomass.

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

This study shows that APOE deficiency in human iPSC-derived cerebral organoids disrupts lipid homeostasis and affects cholesterol biosynthesis and neurogenesis.

Ticagrelor combined with aspirin displays the signature of regulating the gut microbiome in consistence with improving the immuno-inflammatory response in atherosclerosis

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

Effects of seasonal changes on the carbon dynamics in mixed coniferous forests

This study examines seasonal changes in litter and soil carbon dynamics in mixed coniferous forests through freeze-thaw experiments, revealing how temperature fluctuations affect carbon release and mass loss.

The senescence regulator S40 family members from Caragana intermedia and Arabidopsis thaliana inhibit leaf senescence via promoting cytokinins synthesis

This study identifies CiS40-11 and its orthologs AtS40-5 and AtS40-6 as regulators of leaf senescence that promote cytokinin synthesis by inhibiting MYB2 expression.

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell- Mediated Tolerance

This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

Reversable deformation of artificial cell colony for muscle behavior mimicry triggered by actin polymerization

This paper develops self-powered artificial cell colonies that mimic muscle behavior through actin polymerization and depolymerization, showing reversible deformation and collective contraction.

Interleukin-6 Signaling Mediates Cartilage Degradation and Pain in Post-Traumatic Osteoarthritis

This study shows IL-6 signaling contributes to PTOA cartilage degradation and pain through gender-specific downstream mechanisms.

High-throughput production of functional prototissues capable of producing NO for vasodilation

This study develops a high-throughput method to produce functional prototissues that generate nitric oxide, inducing vasodilation in rat blood vessels.

Plakoglobin and HMGB1 mediate intestinal epithelial cell apoptosis induced by Clostridioides difficile TcdB

This study identifies plakoglobin and HMGB1 as key mediators of TcdB-induced intestinal epithelial cell apoptosis through mitochondrial pathways.

Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors

The paper measures forces during clathrin-mediated endocytosis in fission yeast using new in vivo force sensors, revealing force redistribution across the endocytic machinery.