MicrobiologybioRxiv
Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
Y. Hikichi, R. Van Duyne, P. Pham…·E. O. Freed
This study shows that HIV-1 envelope glycoprotein mutations can confer broad antiretroviral resistance through cell-cell transmission and structural changes, independent of target-gene mutations.
DOI 10.1128/mbio.03134-20