BioengineeringbioRxiv
Engineering the substrate specificity of toluene degrading enzyme XylM using biosensor XylS and machine learning
Y. Ogawa, Y. Saito, H. Yamaguchi…·Y. Ohnishi
This paper uses a biosensor and machine learning to engineer XylM for improved substrate specificity, achieving 15 times higher productivity than the wild-type.
DOI 10.1021/acssynbio.2c00577