BiophysicsbioRxiv
Undersampling and the inference of coevolution in proteins
Y. Kleeorin, W. P. Russ, O. Rivoire, R. Ranganathan
This paper shows that current methods for inferring protein coevolution are biased due to undersampling and scale mismatches in epistatic interactions.
DOI 10.1016/j.cels.2022.12.013