BiochemistrybioRxivPreprint
Na+/H+ antiporter activity by respiratory complex I controls mitochondrial Δ{psi} and is impaired in LHON disease
P. Hernansanz-Agustin, C. Morales-Vidal, E. Calvo…·J. A. Enriquez
The paper identifies the P-module of complex I as the Na+/H+ antiporter in mitochondria, showing its role in maintaining ΔΨmt and its dysfunction in LHON disease.
DOI 10.1101/2023.05.30.542932