ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
S. Aykul, L. Huang, L. Wang, N. Das, S. Reisman, Y. Ray, Q. Zhang, N. Rothman, K. C. Nannuru, V. Kamat, S. Brydges, L. Troncone, L. Johnsen, P. B. Yu, S. Fazio, , S. J. Hatsell
This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.
bioRxiv · Jul 18, 2021Biochemistry