Author

S. Brydges

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

A. N. Economides· 3 shared A. J. Murphy· 2 shared L. Wang· 2 shared S. Aykul· 2 shared S. J. Hatsell· 2 shared V. Idone· 2 shared A. D. Baik· 1 shared A. Mehra· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

A. N. Economides

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3 papers

Recent·Most cited

Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch

W. W. Hom, S. Aykul, L. Panagis, K. Patel, S. Brydges, E. J. Goebel, K. N. Lydon, J. B. Lees-Shepard, S. J. Hatsell, V. Idone, A. N. Economides

The paper shows that ActA forms non-signaling complexes with ACVR1 that are trafficked to lysosomes and degraded, unlike Activin B, AC, and AB which remain on the surface.

bioRxiv · Jan 29, 2024 · PreprintCell Biology

ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

S. Aykul, L. Huang, L. Wang, N. Das, S. Reisman, Y. Ray, Q. Zhang, N. Rothman, K. C. Nannuru, V. Kamat, S. Brydges, L. Troncone, L. Johnsen, P. B. Yu, S. Fazio, , S. J. Hatsell

This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.

bioRxiv · Jul 18, 2021Biochemistry

Targeted delivery of acid alpha-glucosidase corrects skeletal muscle phenotypes in Pompe disease mice

A. D. Baik, P. T. Calafati, N. A. Aaron, A. Mehra, S. Moller-Tank, L. Miloscio, L. Wang, M. Praggastis, M. S. Birnbaum, C. Pan, S. Brydges, A. O. Mujica, P. Barbounis, N. W. Gale, N. Li, , K. D. Cygnar

This study demonstrates that targeted enzyme replacement therapy using antibody-enzyme fusion proteins improves skeletal muscle phenotypes in Pompe disease mice compared to standard enzyme replacement therapy.

bioRxiv · Apr 22, 2020 · PreprintBioengineering