Identification of Aryl Hydrocarbon Receptor as a Barrier to HIV-1 Infection and Outgrowth in CD4+ T-Cells
D. Chatterjee, Y. Zhang, T. R. Wiche Salinas, C.-D. Ngassaki-Yoka, H. Chen, Y. Smail, J.-P. Goulet, B. Bell, J.-P. Routy, P. Ancuta
This study identifies AhR as a barrier to HIV-1 infection and outgrowth in Th17-polarized CD4+ T-cells and suggests AhR inhibitors could enhance viral outgrowth in HIV-1 cure strategies.
bioRxiv · Oct 17, 2022Immunology