Author

Y. Sobu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

H. S. Dhekne· 3 shared S. R. Pfeffer· 3 shared D. R. Alessi· 1 shared E. G. Vides· 1 shared F. Diez· 1 shared F. Tonelli· 1 shared H. Komano· 1 shared H. Saito· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCell Biology

H. S. Dhekne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

S. S. Khan, Y. Sobu, H. S. Dhekne, F. Tonelli, K. Berndsen, D. R. Alessi, S. R. Pfeffer

The paper shows that LRRK2 mutations and PPM1H loss cause cilia loss in neurons and astrocytes, disrupting Hedgehog signaling in the nigral-striatal pathway.

bioRxiv · Mar 2, 2021Cell Biology

Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid

S. Hata, K. Kikuchi, K. Kano, H. Saito, Y. Sobu, S. Kinoshita, T. Saito, T. C. Saido, Y. Sano, H. Taru, J. Aoki, H. Komano, T. Tomita, S. Natori, T. Suzuki

This study shows that c9,t11 CLA reduces amyloid-beta production in neurons by altering BACE1 and APP localization, potentially protecting against neurodegeneration.

bioRxiv · Sep 13, 2020Biochemistry

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

I. Yanatori, H. S. Dhekne, E. G. Vides, Y. Sobu, F. Diez, S. R. Pfeffer

This study identifies LRRK2-phosphorylated Rab10 as a key factor in sequestering Myosin Va and RILPL2, blocking ciliogenesis in RPE cells.

bioRxiv · Apr 28, 2020Cell Biology

Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2

Y. Sobu, P. S. Wawro, H. S. Dhekne, S. R. Pfeffer

This study shows that pathogenic LRRK2 mutations reduce ciliation probability by blocking TTBK2 recruitment to the mother centriole, leading to ciliary decapitation in response to serum addition.

bioRxiv · Apr 7, 2020Cell Biology