Author

J. Aoki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Inoue· 2 shared K. Kano· 2 shared O. Nureki· 2 shared W. Shihoya· 2 shared A. Cartier· 1 shared A. Engler· 1 shared A. Kuo· 1 shared A. O'Connor· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

A. Inoue

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural basis for lysophosphatidylserine recognition by GPR34

T. Izume, R. Kawahara, A. Uwamizu, L. Chen, S. Yaginuma, J. Omi, H. Kawana, F. K. Sano, T. Tanaka, K. Kobayashi, H. H. Okamoto, Y. Kise, T. Ohwada, J. Aoki, W. Shihoya, O. Nureki

This study presents cryo-EM structures of GPR34-Gi complex bound with LysoPS analogs, revealing ligand recognition mechanisms and identifying 2-acyl LysoPS as the physiological ligand.

bioRxiv · Feb 15, 2023Biochemistry

Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid

S. Hata, K. Kikuchi, K. Kano, H. Saito, Y. Sobu, S. Kinoshita, T. Saito, T. C. Saido, Y. Sano, H. Taru, J. Aoki, H. Komano, T. Tomita, S. Natori, T. Suzuki

This study shows that c9,t11 CLA reduces amyloid-beta production in neurons by altering BACE1 and APP localization, potentially protecting against neurodegeneration.

bioRxiv · Sep 13, 2020Biochemistry

Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis

I. Ninou, I. Sevastou, C. Magkrioti, E. Kaffe, G. Stamatakis, S. Thivaios, G. Panayotou, J. Aoki, G. Kollias, V. Aidinis

The paper shows that deleting Autotaxin in CD11b+ cells reduces experimental autoimmune encephalomyelitis severity, indicating a pathogenic role for the ATX/LPA axis in neuroinflammation.

bioRxiv · Nov 20, 2019Immunology

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

S. Meckelmann, J. Hawksworth, D. White, R. Andrews, P. Rodrigues, A. O'Connor, J. Alvarez Jarreta, V. Tyrrell, C. Hinz, Y. Zhou, J. Williams, M. Aldrovandi, W. J. Watkins, A. Engler, D. Slatter, , V. B. O'Donnell

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

bioRxiv · Oct 2, 2019Physiology

Crystal structure of human endothelin ETB receptor in complex with peptide inverse agonist IRL2500

C. Nagiri, W. Shihoya, A. Inoue, F. M. Ngako Kadji, J. Aoki, O. Nureki

The paper reports the crystal structure of the human ETB receptor complexed with the inverse agonist IRL2500, revealing its binding mechanism and ETB-selectivity.

bioRxiv · Nov 2, 2018Biochemistry

Heterotypic inter-GPCR β-arrestin coupling regulates lymphatic endothelial junctional architecture in murine lymph nodes

Y. Hisano, M. Kono, E. Engelbrecht, K. Kawakami, K. Yanagida, A. Cartier, S. Galvani, A. Kuo, Y. Ono, S. Ishida, J. Aoki, R. L. Proia, A. Inoue, T. Hla

The paper identifies LPAR1-induced S1PR1/β-arrestin coupling as a mechanism regulating lymphatic endothelial junctional architecture in murine lymph nodes.

bioRxiv · Oct 4, 2018Cell Biology