S. Hata

Flow zoometry of Drosophila

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

An antioxidant screen identifies ascorbic acid for prevention of light-induced mitotic prolongation in live cell imaging

This study identifies ascorbic acid as an effective antioxidant to prevent light-induced mitotic defects in live cell imaging of human diploid cells.

ssDNA is not superior to dsDNA as long HDR donors for CRISPR-mediated endogenous gene tagging in human diploid cells

This study compares ssDNA and dsDNA as HDR donors for CRISPR-mediated gene tagging in human diploid cells, finding dsDNA more efficient for precise insertion.

A CRISPR-del-based pipeline for complete gene knockout in human diploid cells

This study introduces a CRISPR-del pipeline to achieve complete gene knockout in human diploid cells by inducing large chromosomal deletions, showing higher efficiency than conventional methods.

SCFFbxw5 targets MCAK in G2/M to facilitate ciliogenesis in the following cell cycle

The paper identifies SCFFbxw5 as a regulator of MCAK levels during G2/M, showing that its loss impairs ciliogenesis in the subsequent G1 phase.

Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid

This study shows that c9,t11 CLA reduces amyloid-beta production in neurons by altering BACE1 and APP localization, potentially protecting against neurodegeneration.

DONSON, a gene responsible for microcephalic primordial dwarfism, ensures proper centriole duplication cycle by maintaining centriole engagement during interphase.

This study shows that DONSON regulates centriole duplication by maintaining centriole engagement during interphase, and its loss causes centrosome overduplication and chromosome segregation errors in MPD patient cells.

Cep57 and Cep57L1 cooperatively maintain centriole engagement during interphase to ensure proper centriole duplication cycle

This study shows that Cep57 and Cep57L1 work together to keep centrioles engaged during interphase, preventing premature disengagement and ensuring proper centriole duplication and chromosome segregation.

Analysis of LRRC45 indicates cooperative functions of distal appendages at early steps of ciliogenesis

This study identifies LRRC45's role in ciliogenesis by showing it recruits FBF1 to the mother centriole and promotes cilia biogenesis in CP110-uncapped centrioles.