Cell BiologybioRxiv
Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
S. Watanuki, H. Kobayashi, Y. Sugiura…·K. Takubo
This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.
DOI 10.7554/elife.87674