Cancer BiologybioRxiv
Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
D. P. Duarte, A. J. Lamontanara, G. La Sala…·O. Hantschel
This study identifies the Btk SH2-kinase interface as critical for activation and shows that targeting it with a repebody inhibits B-cell neoplasms.
DOI 10.1038/s41467-020-16128-5