Author

Y.-L. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Assay:metagenomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P.-H. Wang· 3 shared T.-H. Lee· 3 shared T.-Y. Wu· 3 shared Y.-L. Chen· 3 shared Y.-R. Chiang· 3 shared C.-H. Chou· 2 shared C.-J. Shih· 2 shared M.-J. Chen· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

P.-H. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development

M.-J. Chen, C.-H. Chou, T.-H. Hsiao, T.-Y. Wu, C.-Y. Li, Y.-L. Chen, K.-H. Chao, T.-H. Lee, R. Gicana, C.-J. Shih, G.-J. Brandon-Mong, Y.-L. Lai, P.-T. Li, Y.-L. Tseng, P.-H. Wang, Y.-R. Chiang

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.

Gut Microbes · Nov 7, 2024Peer-reviewedMicrobiology

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

Y.-L. Lai, C.-C. Wang, Y.-L. Lin, P.-C. Shen, M.-H. Tsai, F.-H. Chen, W.-C. Cheng

The paper identifies miR-4776-5p as a radiosensitizer in head and neck cancer that predicts patient prognosis during radiotherapy.

bioRxiv · Dec 27, 2022 · PreprintCancer Biology

Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

T.-H. Hsiao, C.-H. Chou, Y.-L. Chen, P.-H. Wang, G.-J. B. Mong, T.-H. Lee, T.-Y. Wu, P.-T. Li, C.-W. Li, Y.-L. Lai, Y.-L. Tseng, C.-J. Shih, M.-J. Chen, Y.-R. Chiang

This study shows that oral administration of Thauera sp. strain GDN1 reduces serum androgen levels in male mice by catabolizing androgens in the gut.

bioRxiv · Jul 20, 2022Microbiology

Integrated multi-omics investigations reveal the key role of synergistic microbial networks in removing plasticizer di-(2-ethylhexyl) phthalate from estuarine sediments

S. T.-S. Wei, Y.-L. Chen, Y.-W. Wu, T.-Y. Wu, Y.-L. Lai, P.-H. Wang, W. Ismail, T.-H. Lee, Y.-R. Chiang

This study identifies synergistic microbial networks in estuarine sediments that degrade DEHP, with Acidovorax and Sedimenticola as key degraders and horizontal gene transfer playing a role in DEHP degradation capacity.

bioRxiv · Mar 24, 2021Microbiology