Author

P.-H. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 12 Biochemistry· 1 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 13 Research Focus:host-pathogen & immune response· 11 Organism:human· 6 Assay:metabolomics· 4 Assay:proteomics· 4 Assay:metagenomics· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

Y.-L. Chen· 6 shared Y.-R. Chiang· 6 shared T.-H. Lee· 5 shared T.-H. Hsiao· 4 shared T.-Y. Wu· 4 shared J. Zhang· 3 shared M.-W. Zhuang· 3 shared Y.-L. Lai· 3 shared

Activity by Year

2018-2024 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersMicrobiology

Y.-L. Chen

Mutual co-authors in cluster

Author profile →

15 papers

Recent·Most cited

Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development

M.-J. Chen, C.-H. Chou, T.-H. Hsiao, T.-Y. Wu, C.-Y. Li, Y.-L. Chen, K.-H. Chao, T.-H. Lee, R. Gicana, C.-J. Shih, G.-J. Brandon-Mong, Y.-L. Lai, P.-T. Li, Y.-L. Tseng, P.-H. Wang, Y.-R. Chiang

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.

Gut Microbes · Nov 7, 2024Peer-reviewedMicrobiology

Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

T.-H. Hsiao, C.-H. Chou, Y.-L. Chen, P.-H. Wang, G.-J. B. Mong, T.-H. Lee, T.-Y. Wu, P.-T. Li, C.-W. Li, Y.-L. Lai, Y.-L. Tseng, C.-J. Shih, M.-J. Chen, Y.-R. Chiang

This study shows that oral administration of Thauera sp. strain GDN1 reduces serum androgen levels in male mice by catabolizing androgens in the gut.

bioRxiv · Jul 20, 2022Microbiology

Sensitive and specific miRNA in situ hybridization using partially methylated phosphotriester antisense DNA probes

P.-H. Wang, C.-W. Chang, T. Z. Jia, B. C.-M. Tan, Y.-H. Chi, W.-Y. Chen

This study demonstrates that partially methylated nDNA probes enhance miRNA detection specificity and sensitivity in in situ hybridization compared to conventional DNA probes.

bioRxiv · Jun 12, 2022 · PreprintBioengineering

Identification of essential β-oxidation genes and corresponding metabolites for estrogen degradation by actinobacteria

T.-H. Hsiao, T.-H. Lee, M.-R. Chuang, P.-H. Wang, M. Meng, M. Horinouchi, T. Hayashi, Y.-L. Chen, Y.-R. Chiang

This study identifies essential β-oxidation genes and metabolites involved in estrogen degradation by actinobacteria using transcriptomics, gene disruption, and metabolite profiling.

bioRxiv · Apr 22, 2021Microbiology

Integrated multi-omics investigations reveal the key role of synergistic microbial networks in removing plasticizer di-(2-ethylhexyl) phthalate from estuarine sediments

S. T.-S. Wei, Y.-L. Chen, Y.-W. Wu, T.-Y. Wu, Y.-L. Lai, P.-H. Wang, W. Ismail, T.-H. Lee, Y.-R. Chiang

This study identifies synergistic microbial networks in estuarine sediments that degrade DEHP, with Acidovorax and Sedimenticola as key degraders and horizontal gene transfer playing a role in DEHP degradation capacity.

bioRxiv · Mar 24, 2021Microbiology

Sequential ER stress and inflammatory responses are induced by SARS-CoV-2 ORF3 through ERphagy

X. Zhang, Z. Yang, X. Long, Q. Sun, F. Wang, P.-h. Wang, X. Li, E. Kuang

This study identifies SARS-CoV-2 ORF3 as an inducer of ERphagy, leading to ER stress and inflammatory responses, which may be targeted for COVID-19 treatment.

bioRxiv · Nov 17, 2020 · PreprintMicrobiology

Genetic and metabolite biomarkers reveal actinobacteria-mediated estrogen biodegradation in urban estuarine sediment

T.-H. Hsiao, Y.-L. Chen, M. Meng, M.-R. Chuang, M. Horinouchi, T. Hayashi, P.-H. Wang, Y.-R. Chiang

This study identifies actinobacterial genes and metabolites involved in estrogen degradation in urban estuarine sediments and finds actinobacteria, not proteobacteria, are primarily responsible for estrogen breakdown.

bioRxiv · Oct 7, 2020 · PreprintMicrobiology

SARS-CoV-2 ORF9b Antagonizes Type I and III Interferons by Targeting Multiple Components of RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING Signaling Pathways

L. Han, M.-W. Zhuang, Y. Zheng, J. Zhang, M.-L. Nan, P.-H. Wang, C. Gao

This study identifies SARS-CoV-2 ORF9b as a viral protein that inhibits type I and III interferon responses by disrupting multiple innate antiviral signaling pathways.

bioRxiv · Aug 16, 2020Microbiology

A Systemic and Molecular Study of Subcellular Localization of SARS-CoV-2 Proteins

J. Zhang, R. Cruz-cosme, M.-W. Zhuang, D. Liu, Y. Liu, S. Teng, P.-H. Wang, Q. Tang

This study characterizes the subcellular localization of SARS-CoV-2 proteins using expression in human cells and immunofluorescent assays, revealing their association with various organelles.

bioRxiv · Aug 2, 2020Microbiology

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) Protein Inhibits Type I and III Interferon Production by Targeting RIG-I/MDA-5 Signaling

P.-H. Wang, Y. Zheng, M.-W. Zhuang, L. Han, J. Zhang, M.-L. Nan, C. Gao

This study identifies the SARS-CoV-2 M protein as an inhibitor of type I and III interferon production by disrupting RIG-I/MDA-5 signaling, thereby suppressing antiviral immunity and enhancing viral replication.

bioRxiv · Jul 26, 2020Immunology

Biochemically diverse CRISPR-Cas9 orthologs

G. Gasiunas, J. K. Young, T. Karvelis, D. Kazlauskas, T. Urbaitis, M. Jasnauskaite, M. Grusyte, S. Paulraj, P.-H. Wang, Z. Hou, S. K. Dooley, M. Cigan, C. Alarcon, N. D. Chilcoat, G. Bigelyte, , V. Siksnys

The paper characterizes the biochemical diversity of CRISPR-Cas9 orthologs, identifying varied PAM recognition and gRNA requirements across 79 Cas9 proteins.

bioRxiv · Apr 29, 2020 · PreprintBiochemistry

Increasing Host Cellular Receptor--Angiotensin-Converting Enzyme 2 (ACE2) Expression by Coronavirus may Facilitate 2019-nCoV Infection

P.-H. Wang

This study shows that coronavirus infection increases ACE2 receptor expression, potentially facilitating viral entry and spread, suggesting ACE2-targeting drugs could be developed for future outbreaks.

bioRxiv · Feb 24, 2020Microbiology

Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation

P.-H. Wang, Y.-L. Chen, S. T.-S. Wei, K. Wu, T.-H. Lee, T.-Y. Wu, Y.-R. Chiang

The paper identifies a bacterial strain capable of converting estrogens into androgens via cobalamin-mediated methylation, revealing a novel metabolic pathway.

bioRxiv · Jul 25, 2019Microbiology

Sustained dechlorination of vinyl chloride to ethene in Dehalococcoides-enriched cultures grown without addition of exogenous vitamins and at low pH

L. A. Puentes Jacome, P.-H. Wang, O. Molenda, Y. X. Li, M. A. Islam, E. A. Edwards

This study shows that Dehalococcoides-enriched cultures can sustain TCE dechlorination to ethene at low pH without exogenous vitamins, but VcrA activity declines below pH 6.0.

bioRxiv · Apr 18, 2019Microbiology

Interspecies malate-pyruvate shuttle drives amino acid exchange in organohalide-respiring microbial communities

P.-H. Wang, K. Correia, H.-C. Ho, N. Venayak, K. Nemr, R. Flick, R. Mahadevan, E. A. Edwards

This study identifies an interspecies malate-pyruvate shuttle in microbial communities that enables amino acid exchange under redox constraints.

bioRxiv · Aug 1, 2018Microbiology