Author

W.-C. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:drug response / drug discovery· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:deep learning· 3 Research Focus:differential expression· 3 Assay:proteomics· 3

Frequent Co-Authors

C.-Y. Lin· 3 shared I.-H. Lu· 3 shared S.-H. Chen· 3 shared T.-T. Lin· 3 shared Y.-Y. Sun· 2 shared A. L. Harris· 1 shared A. M. Egloff· 1 shared A. Mcintyre· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

C.-Y. Lin

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

M. S. Taylor, W. Connie, P. C. Fridy, S. J. Zhang, Y. Senussi, J. C. Wolters, W.-C. Cheng, J. Heaps, B. D. Miller, K. Mori, L. Cohen, H. Jiang, K. R. Molloy, B. L. Norden, B. T. Chait, , O. H. Yilmaz

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

bioRxiv · Jan 25, 2023 · PreprintCancer Biology

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

Y.-L. Lai, C.-C. Wang, Y.-L. Lin, P.-C. Shen, M.-H. Tsai, F.-H. Chen, W.-C. Cheng

The paper identifies miR-4776-5p as a radiosensitizer in head and neck cancer that predicts patient prognosis during radiotherapy.

bioRxiv · Dec 27, 2022 · PreprintCancer Biology

Antimicrobial Susceptibility Test by Surface-enhanced Raman Scattering of Bacterial Metabolites directly from Positive Blood Cultures

Y.-Y. HAN, J.-T. Wang, W.-C. Cheng, K.-L. Chen, Y. Chi, L.-J. Teng, J.-K. Wang, Y.-L. Wang

This study develops SERS-AST, a rapid antimicrobial susceptibility test using surface-enhanced Raman scattering of bacterial metabolites from positive blood cultures, achieving high agreement with VITEK 2 results.

bioRxiv · Mar 23, 2022 · PreprintMicrobiology

Peptide-based drug predictions for cancer therapy using deep learning

Y.-Y. Sun, T.-T. Lin, W.-C. Cheng, I.-H. Lu, S.-H. Chen, C.-Y. Lin

This paper develops AI4ACP, a web-server for predicting anticancer peptides, showing improved performance over existing predictors.

bioRxiv · Feb 1, 2022Cancer Biology

Developing an Antiviral Peptides Predictor with Generative Adversarial Network Data Augmentation

T.-T. Lin, Y.-Y. Sun, W.-C. Cheng, I.-H. Lu, S.-H. Chen, C.-Y. Lin

The paper develops a binary classifier for identifying antiviral peptides using a GAN-augmented dataset and achieves high performance on a test set.

bioRxiv · Nov 29, 2021 · PreprintMicrobiology

AI4AMP: Sequence-based antimicrobial peptides predictor using physicochemical properties-based encoding method and deep learning

T.-T. Lin, L.-Y. Yang, I.-H. Lu, W.-C. Cheng, Z.-R. Hsu, S.-H. Chen, C.-Y. Lin

AI4AMP predicts antimicrobial activity of protein sequences using physicochemical properties encoding and deep learning, outperforming existing predictors.

bioRxiv · Dec 17, 2020 · PreprintMicrobiology

Hypoxia-induced SETX links replication stress with the unfolded protein response

S. Ramachandran, T. Ma, N. Ng, I. Foskolou, M.-S. Hwang, P. Victori, W.-C. Cheng, F. M. Buffa, K. Leszczynska, N. Gromak, E. M. Hammond

This study shows hypoxia induces SETX, which protects cells from DNA damage by linking replication stress and the unfolded protein response.

bioRxiv · May 24, 2020Cancer Biology

Low-Density Lipoprotein Receptor-Mediated Lipidome-Transcriptome Reprogramming Impulses to Cisplatin Insensitivity

W.-C. Chang, H.-C. Wang, W.-C. Cheng, J.-C. Yang, W.-M. Chung, L. Chen, Y.-P. Ho, Y.-C. Hung, W.-L. Ma

This study identifies LDLR-mediated lipidome-transcriptome reprogramming as a mechanism for cisplatin insensitivity in ovarian cancer and demonstrates a lipid-based drug delivery strategy to enhance chemotherapy efficacy.

bioRxiv · Dec 21, 2018 · PreprintCancer Biology

AICAR induces apoptosis and inhibits migration of prostate cancer cells through an AMPK/mTOR-dependent pathway

C.-C. Su, K.-L. Hsieh, S.-C. Wang, H.-C. Yeh, S.-P. Huang, P.-L. Liu, S.-H. Fang, W.-C. Cheng, K.-H. Huang, F.-Y. Chiu, I.-L. Lin, M.-Y. Huang, C.-Y. Li

This study shows AICAR inhibits prostate cancer cell growth, induces apoptosis, reduces migration, and enhances chemosensitivity via the AMPK/mTOR pathway.

bioRxiv · Nov 19, 2018Cancer Biology

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine-resistance in breast cancer

M. Morotti, E. Bridges, A. Valli, H. Choudhry, H. Sheldon, S. Wigfield, N. Gray, D. Jones, E. J. Teoh, W.-C. Cheng, S. Lord, S. Haider, A. Mcintyre, D. C. I. Goberdhan, F. Buffa, A. L. Harris

This study shows hypoxia shifts SNAT2 regulation from ER to HIF-1 in breast cancer, leading to endocrine resistance and poor outcomes.

bioRxiv · Aug 3, 2018Cancer Biology