Author

Yan Guo

Division of Biostatistics and Bioinformatics, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA;

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Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Alexander ZaikaiD· 1 shared Bao Tran· 1 shared Castle Raley· 1 shared Cheryl Heiner· 1 shared Chris M. Li· 1 shared Clarisel C. Lozano· 1 shared Claudia Stewart· 1 shared Daniel R Soppet· 1 shared

Activity by Year

2014-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Alexander ZaikaORCID

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3 papers

Recent·Most cited

Single-Cell Transcriptomics Reveals Tumorigenic Lineages and Interactions Persisting and Evolving From Premalignancy to Cancer in the Stomach

Emily N. Vazquez, Clarisel C. Lozano, Xiaodian Sun, Dyana Torres Juvier, Chris M. Li, Wael El-Rifai, Alexander Zaika, Yuguang Ban, Yan Guo, Xiaodong Cai, Zhibin Chen

The paper uses single-cell transcriptomics to track molecular changes from premalignancy to cancer in gastric tissue, identifying persistent and evolving tumorigenic lineages and markers like EMB.

bioRxiv · Nov 6, 2026 · PreprintCancer Biology

Metabolomic analysis of Chinese chestnut (Castanea mollissima Bl.) leaves in response to Oligonychus ununguis feeding stress

Xinfang Zhang, Shuhang Zhang, Ying Li, Yan Guo, Jinyu Liu, Jiayi Liu, Liying Fan, Guangpeng Wang

The paper analyzes metabolomic changes in Chinese chestnut leaves under mite stress, identifying key phenylpropanoids and flavonoids associated with resistance.

bioRxiv · Nov 20, 2025 · PreprintPlant Biology

Preparation of next-generation DNA sequencing libraries from ultra-low amounts of input DNA: Application to single-molecule, real-time (SMRT) sequencing on the Pacific Biosciences RS II.

Castle Raley, David Munroe, Kristie Jones, Yu-Chih Tsai, Yan Guo, Bao Tran, Sujatha Gowda, Jennifer L. Troyer, Daniel R Soppet, Claudia Stewart, Robert Stephens, Jack Chen, TF Skelly, Cheryl Heiner, Jonas Korlach, Dwight Nissley

The paper develops an amplification-free method for preparing DNA sequencing libraries from very low DNA input for PacBio SMRT sequencing, achieving comparable yields with 1000-fold less starting material.

bioRxiv · Mar 25, 2014 · PreprintGenomics